Carina Ankarberg-Lindgren Kerstin Larsson Charlotte Becker Göran Brattsand 2012 09 10 Mätmetoder för östradiol och testosteron Equalis användarmöte endokrinologi i 2012
Siemens Coat-a-Count a Count total Testosterone PITKTT-4, 2005-03-18 Analytical sensitivity: 0,14 nmol/l Klinisk kemi Umeå 2011 04 01 Byte från Siemens Coat-a-Count RIA till Cobas Testosteron II Svarsformat oförändrat < 0,2 nmol/l som < 0,2 nmol/l
ERM-DA346a 089± 0,89 024 0,24 nmol/l ERM-DA345a 19,7 ± 14 1,4 nmol/l 0,65 1,13 18,3 21,1 Siemens 0,9 18,6 Coat-a-Count RIA Roche Cobas Testosterone II 0,86 19,0
S-Testosteron LC-MS/MS HUS-lab (nmol/l) Laboratoriemedicin Västerbottens läns landsting
S-Testosteron LC-MS/MS HUS-lab (nmol/l) Laboratoriemedicin Västerbottens läns landsting
tio Rat Siemens Coat a Count DPC 18 1.8 1.6 0.8 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Ratio 1.8 1.6 1.0 0.8 0.2 Roche Cobas (II) 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Ratio Siemens Coat a Count DPC 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Ratio Roche Cobas (II) 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Groenestege, Clin Chem 2012;58: 1154 + Suppl info
3500 25 största kunderna för testosteron i Umeå 2011 05 01-2012 08 30 n = 7346 3000 2500 resultat Antal 2000 1500 1000 500 0 Kund
3278 testosteronanalyser beställda från onkologi avd/mott Umeå på män. 1581 (48%) < 1 nmol/l 1055 (32%) < 0,2 nmol/l (ej påvisbart)
Kan kombinerade p-piller piller ge falskhögt testosteron? Noretisteron? Mini-Pe Orthonett Smfase Symfase Trinovum Levonorgestrel? Abelonelle Nevoletta Norlevo Postinor Prionelle Trinordiol Triregol
Funkar testosteronmätningar på dialyspatienter?
20 ng/dl = 0,7 nmol/l
Testosteron Testoste ron II Roch he Cobas 20 15 10 5 y = 0,97x - 1,5 R² = 0,98 Män Kvinnor Linjär (Män) Linjär (Kvinnor) y = 0,60x - 0,6 R² = 0,81 0 0 5 10 15 20 Abbott Architect 2012-09-13 Laboratoriemedicin Dalarna
Abs Diff testosteron 0,5 0-0,5 0 5 10 15 20 obas -1 15-2 Diff C-1,5 Män Kvinnor -2,5 25-3 -3,5 Architect 2012-09-13 Laboratoriemedicin Dalarna
Ra atio Abbott Architect i2000 (I) 18 1.8 1.6 0.8 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Ra atio Roche Cobas (II) 18 1.8 1.6 0.8 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Abbott Architect i2000 (II) 1.8 1.6 Ratio 1.0 0.8 0.2 40 4.0 80 8.0 1 16.0 20 24.0 28.0 3 36.0 40 Groenestege, Clin Chem 2012;58: 1154 + Suppl info
Ratio Ratio 10 9.0 8.0 7.0 60 6.0 5.0 4.0 3.0 20 1.0 Abbott Architect i2000 (I) 0.5 1.0 1.5 2.5 3.0 3.5 4.0 1 9.0 80 8.0 7.0 6.0 5.0 40 4.0 3.0 1.0 Abbott Architect i2000 (II) 00 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Ratio 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 Roche Cobas (II) 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Groenestege, Clin Chem 2012;58: 1154 + Suppl info
Beckman DxI och Roche Cobas 601 Labmedicin Skåne Klinisk Kemi
Serum-Testosteron jmf Beckman DxI mot Roche Cobas 601 våren 2011 i Malmö Alla (n=40) Låga intervallet t Testo (0,1-32,3) Testo (0,1-3,0) Roche Cobas II 35,0 30,0 25,0 20,0 15,0 10,0 y = 1,38x - 0,91 R2 = 0,99 Cobas II Roche 3,5 3 2,5 2 1,5 1 y = 0,81x + 0,01 R 2 = 0,68 5,0 0,5 0,0 0,0 5,0 10,0 15,0 20,0 25,0 30,0 35,0 Beckman DXI 0 0 0,5 1 1,5 2 2,5 3 3,5 Beckman DXI
Ratio Rat tio Beckman Coulter Access 1.8 1.6 0.8 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Beckman Coulter Access 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 00 05 0.5 15 1.5 20 25 2.5 30 3.0 35 3.5 40 4.0 Ratio Ra atio Roche Cobas (II) 18 1.8 1.6 0.8 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Roche Cobas (II) 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 00 05 0.5 15 1.5 20 25 2.5 30 3.0 35 3.5 40 4.0 Groenestege, Clin Chem 2012;58: 1154 + Suppl info
Testosteron (materil HbE = serumpool) 2010-2012 Material HbE 14 12 10 Res sultat 8 6 4 2 0 Rapportgrupp
Testosteron HbE = serumpool 14 2010-2012 Material HbE 12 10 ultat Res 8 6 4 2 0 Rapportgrupp Ra atio Abbott Architect i2000 (I) Beckman Coulter Access Roche Cobas (II) 1.8 1.8 1.8 1.6 1.6 1.6 0.8 0.8 0.8 0.2 0.2 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Ra atio Ra atio
Testosteron HbE = serumpool 14 2010-2012 Material HbE 12 10 ultat Res 8 6 4 2 0 Rapportgrupp Ra atio Siemens ADVIA Centaur 20 1.8 1.6 1.0 0.8 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 1.8 1.6 0.8 0.2 Siemens Coat a Count DPC Siemens Immulite 2000 20 1.8 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 1.6 1.0 0.8 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4
Beckman DxI och Roche Cobas 601 Labmedicin Skåne Klinisk Kemi
Serum Östradiol jmf Beckman DxI mot Roche Cobas 601 våren 2011 i Malmö Alla (n=40) Låga intervallet E2 (81-3571) E2 (24-770) Roche Co obas II 4000 3000 2000 1000 y = 1,18x + 4,2 R 2 = 0,99 Roche Co obas II 1000 800 600 400 200 y = 1,18x + 5,8 R 2 = 0,92 0 0 1000 2000 3000 4000 Beckman DXI 0 0 200 400 600 800 1000 Beckman DXI
Östradiol (HbE, flytande) 250 2010-2012 2012 Material HbE 200 150 Resul ltat (pmol/l L) 100 50 0 24 Rapportgrupp
S-Testosteron (nmol/l) Jmf Orion Diagnostica Spectria modifierad (LoD 0,03 nmol/l, Tillväxtlab) mot Beckman Dxi (KI). Individer >11 år 10 Equation Weight Residual Sum of Squares y = a + b*x No Weighting 222,53471 Pearson's r 0,96723 Adj. R-Square 0,93416 Value Standard Error B Intercept 0,20089 0,45559 B Slope 1,14973 0,04402 Bec ckman Dxi 1 0,1 0,1 1 10 Orion Diagnostica Spectria
S-Testosteron (nmol/l) Jmf Orion Diagnostica Spectria modifierad d (LoD 0,0303 nmol/l, Tillväxtlab) mot GC-MS/MS (SS). Prepubertal och pubertala barn 10 Equation Weight Residual Sum of Squares y = a + b*x No Weighting 3,33568 Pearson's r 0,99797 Adj. R-Square 0,99561 Value Standard Error B Intercept 0,09786 0,15652 B Slope 1,04885 0,01932 GC C-MS/MS 1 0,1 01 0,1 1 10 Orion Diagnostica Spectria
S-Testosteron (nmol/l) Jmf Orion Diagnostica Spectria modifierad (LoD 0,0303 nmol/l, Tillväxtlab) mot Access och Centaur (SS). Kvinnor. 2,5 2,5 2,0 2,0 Beckman Ac ccess2 15 1,5 1,0 0,5 Equation y = a + b*x Weight No Weighting Residual Sum 1,83817 of Squares Pearson's r 0,63392 Adj. R-Square 0,30217 Value Standard Error Beckman Acces Intercept 0,04521 0,771 Beckman Acces Slope 1,63638 0,81503 taur Siemens Cent 15 1,5 1,0 0,5 Equation Weight Residual Sum of Squares y = a + b*x No Weighting 0,29372 Pearson's r 0,222 Adj. R-Square -0,10917 Value Standard Error Siemens Centa Intercept 0,98124 0,3082 Siemens Centa Slope 0,1817 0,3258 0,5 1,0 1,5 2,0 2,5 Orion Diagnostica Spectria 05 0,5 10 1,0 15 1,5 20 2,0 25 2,5 Orion Diagnostica Spectria
) Direct RIA 17β-o oestradiol in sera (pmol/l) fference (%) Dif 1000 100 10 Alla 1 1 10 100 1000 Extraction RIA 17β-oestradiol in purified samples (pmol/l) 250 200 150 100 50 0-50 -100-150 -200-250 0 50 100 150 200 300 400 500 600 700 1000 800 900 Mean direct RIA and extraction RIA (pmol/l) S-Östradiol (pmol/l). Jmf. Orion Diagnostica Spectria mo med och utan förextraktion. Prepubertala och pubertala barn. Direct RIA 1000 100 30 Equation Weight Residual Sum of Squares E2 >30 pmol/l y = a + b*x No Weighting 0,46385 Pearson's r 0,96869 Adj. R-Square 0,93768 Value Standard Error dir Intercept 0,06389 0,04904 dir Slope 0,956 0,02583 30 100 1000 Extraction ti RIA Ankarberg-Lindgren. Eur J Endocrinol 2008;158:117-124
LFIA ol (pmol/l) AutoDE 17β-oestradio (%) Difference 1000 100 10 1 200 150 100 50 0-50 -100-150 -200 Alla 1 10 100 1000 Extraction Spectria 17β-oestradiol (pmol/l) 0 100 200 300 400600 650 700 750 800 850 1000 900 950 Mean AutoDELFIA and extraction Spectria (pmol/l) S-Östradiol (pmol/l). Jmf. Orion Diagnostica Spectria modifer med förextraktion mot PerkinElmer Auto Prepubertala och pubertala barn. AutoDel lfia 1000 E2 AutoDELFIA >30 pmol/l 100 10 Equation y = a + b*x Weight No Weighting Residual Sum 84890,81778177 of Squares Pearson's r 0,97593 Adj. R-Square 0,95184 Value Standard Error B Intercept 24,85168 4,70593 B Slope 0,95843 0,02395 10 100 1000 Extraction Spectria Ankarberg-Lindgren. Eur J Endocrinol 2008;158:117-124
S-Östradiol (pmol/l).. Jmf. Orion Diagnostica Spectria modifer med förextraktion mot Siemens Immulite Kvinnor. 1000 fertil postmenopausal lite Siem mens Immu 100 10 10 100 1000 Extraktion + Orion Diagnostica Spectria
Ratio 1.8 1.6 1.0 0.8 0.2 Roche Cobas (II) 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Ratio Siemens Coat a Count DPC 1.8 1.6 1.0 0.8 0.2 00 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Ratio Siemens ADVIA Centaur 1.8 16 1.6 1.0 08 0.8 0.2 00 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Ratio Siemens Immulite 2000 1.8 16 1.6 1.0 0.8 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4
Ratio 1.8 1.6 1.0 0.8 0.2 Roche Cobas (II) 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Ratio 1.8 1.6 1.0 0.8 Abbott Architect i2000 (I) 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Abbott Architect i2000 (II) Beckman Coulter Access 1.8 1.8 16 1.6 16 1.6 Ratio 1.0 08 0.8 Ratio 1.0 08 0.8 0.2 0.2 00 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 00 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4
Ratio 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 Siemens Coat a Count DPC 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Ratio 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 Roche Cobas (II) 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Ratio Abbott Architect i2000 (I) 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 00 05 0.5 15 1.5 20 25 2.5 30 3.0 35 3.5 40 4.0 Ratio Beckman Coulter Access 1 9.0 8.0 70 7.0 6.0 5.0 4.0 30 3.0 1.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Groenestege, Clin Chem 2012;58: 1154 + Suppl info
Ratio 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 Siemens Coat a Count DPC 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Ratio 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 Roche Cobas (II) 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Ratio Abbott Architect i2000 (I) 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 00 05 0.5 15 1.5 20 25 2.5 30 3.0 35 3.5 40 4.0 Ratio Beckman Coulter Access 1 9.0 8.0 70 7.0 6.0 5.0 4.0 30 3.0 1.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Groenestege, Clin Chem 2012;58: 1154 + Suppl info
Rat tio Roche Cobas (II) 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 tio Rat Siemens ADVIA Centaur 1 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Ratio Siemens Immulite 2000 1 9.0 8.0 7.0 6.0 5.0 4.0 3.0 1.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Groenestege, Clin Chem 2012;58: 1154 + Suppl info
50 ng/dl = 1,7 nmol/l J Urol 2012; 187: 1601
0,32 nmol/l 0,14 nmol/l J Urol 2012; 187: 1601
Östradiol 2010-2012 Material HbB 1,2 1 0,8 Re esultat 0,6 0,4 0,2 0 Rapportgrupp 39
Testosteron 2010-2012 Material HbB 25 20 Re esultat 15 10 5 0 Rapportgrupp 40
Östradiol 1 2010 20122012 medelvärde d per rapportgrupp och omgång Material HbB, frystorkat 0,9 0,8 0,7 0,6 0,5 0,4 0,3 0,2 Abbott Architect Beckman Coulter UniCel DxI 800 Orion Diagnostica Spectria Ortho Vitros ECi Roche Modular E & cobas e601 Siemens Advia Centaur Siemens Immulite 2500 0,1 0 Hbb (ft) Hbb (ft) Hbb (ft) Hbb (ft) Hbb (ft) Hbb (ft) Hbb (ft) 2010 2010 2010 2011 2011 2011 2012 05/B2 22/B2 40/B1 06/B2 33/B2 41/B1 07/B2 41
Testosteron Material: HbB 25 2010 20122012 medelvärde d per rapportgrupp och omgång Material HbB, frystorkat 20 15 10 5 Abbott Architect Beckman Coulter Access Beckman Coulter UniCel DxI 800 Orion Diagnostica Spectria Ortho Vitros ECi Roche Elecsys & cobas e411 Roche Modular E & cobas e601 Siemens Advia Centaur Siemens Coat A Count Siemens Immulite 2500 0 Hbb (ft) Hbb (ft) Hbb (ft) Hbb (ft) Hbb (ft) Hbb (ft) Hbb (ft) 2010 2010 2010 2011 2011 2011 2012 05/B2 22/B2 40/B1 06/B2 33/B2 41/B1 07/B2 42
Testosteron Material: liquid human serum pool, coded Hbe 14 2010 2012 2012 medelvärde per rapportgrupp och omgång Material HbE, flytande 12 10 Abbott Architect Beckman Coulter Access 8 Beckman Coulter UniCel DxI 800 Orion Diagnostica Spectria 6 Ortho Vitros ECi Roche Modular E & cobas e601 4 Siemens Advia Centaur Siemens Coat A Count Siemens Immulite 2500 2 0 HbE (fly) HbE (fly) HbE (fly) 2010 14/B1 2010 32/B1 2011 15/B1 43
14 Material: liquid human serum pool, cod Testosteron 2010 2012 medelvärde per rapportgrupp och omgång Material HbE, flytande 12 10 8 6 4 2 Abbott Architect Beckman Coulter Access Beckman Coulter UniCel DxI 800 Oi Orion Diagnostica Spectria Ortho Vitros ECi Roche Modular E & cobas e601 Siemens Advia Centaur Siemens Coat A Count Siemens Immulite 2500 0 HbE (fly) HbE (fly) HbE (fly) 2010 14/B1 2010 32/B1 2011 15/B1 44
Testosteron Material: liquid human serum pool, coded Hbe 14 2010 2012 2012 medelvärde per rapportgrupp och omgång Material HbE, flytande 12 10 Abbott Architect Beckman Coulter Access 8 Beckman Coulter UniCel DxI 800 Orion Diagnostica Spectria 6 Ortho Vitros ECi Roche Modular E & cobas e601 4 Siemens Advia Centaur Siemens Coat A Count Siemens Immulite 2500 2 0 HbE (fly) HbE (fly) HbE (fly) 2010 14/B1 2010 32/B1 2011 15/B1 45
6 Testosteron 2010 20122012 medelvärde d per rapportgrupp och omgång Material Hbc, frystorkat Material: HbC 5 4 3 2 1 Abbott Architect Beckman Coulter Access Beckman Coulter UniCel DxI 800 Orion Diagnostica Spectria Ortho Vitros ECi Roche Elecsys & cobas e411 Roche Modular E & cobas e601 Siemens Advia Centaur Siemens Coat A Count Siemens Immulite 2500 0 Hbc (ft) Hbc (ft) Hbc (ft) Hbc (ft) Hbc (ft) Hbc (ft) Hbc (ft) 2010 14/B22010 40/B22010 49/B22011 15/B22011 23/B22011 41/B22012 14/B114/B22010 40/B22010 49/B22011 15/B22011 23/B22011 41/B22012 14/B1 46
Testosteron analyserade i Umeå n = 7347 resultat 2011 05 01 2012 08 30 Cobas Testosteron II Därav barn upp till 12 år åtta st resultat En pojke 6 mån Fem pojkar 6-12 år En pojke 12 år En flicka 12 år 0,3 nmol/l < 0,2 nmol/l 0,8 nmol/l 0,3 nmol/l
Beckman DxI och Roche Cobas 601 Labmedicin Skåne Klinisk Kemi
Östradiol
Delfia vs Roche Estradiol II Delfia vs Roche Cobas (män 18 år) 250 y = 1,0851x + 21,878 R 2 = 0,6901 200 150 S-Östradiol pmol/l Linjär (S-Östradiol pmol/l) 100 50 0 0 50 100 150 200 250
250 Delfia vs Roche Estradiol IIb Östradiol - Delfia vs Roche Cobas (män 20-45 år) y = 0,9087x + 2,7699 R 2 = 0,4811 200 150 E2 pmol/l Linjär (E2 pmol/l) 100 50 0 0 50 100 150 200 250
Delfia vs Roche Estradiol II (aktuell metod) resp Delfia vs Estradiol IIb (modifierad metod) E2 känsligt vs. aktuell metod E2 känsligt vs. modifierad metod 150 120 nsligt E2 kä 100 50 y = 0,4234x + 8,2453 R 2 = 0,7302 E2 kä änsligt 100 80 60 40 y = 0,4236x + 30,314314 R 2 = 0,3828 20 0 0 50 100 150 0 0 20 40 60 80 100 120 Aktuell metod E2 Modifirad metod
Roche Estradiol II vs Estradiol IIb E2 Ny metod vs. aktuell metod 1600 1200 y = 0,9895x - 27,323 R 2 = 0,9972 ny metod vs. aktuell metod Ny me etod 800 400 0 0 400 800 1200 1600 Aktuell metod
E2IIb jämförelse mellan 2 lab Lund Nytt reagens Lot: 166101 vs Malmö Nytt reagens Lot: 166101 1000 800 y = 1,0043x + 15,218 R 2 = 0,9987 600 d Lun 400 200 0 0 200 400 600 800 1000 Malmö
FIGURE 1A Ra tio Abbott Architect i2000 (I) 1 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 tio Ra Abbott Architect i2000 (I) 1 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0
Ra atio Abbott Architect i2000 (II) 1 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 tio Ra Abbott Architect i2000 (II) 1 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0
Ra atio Beckman Coulter Access 1 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Ra atio Beckman Coulter Access 1 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0
1 Siemens Coat a Count DPC 1 Siemens Coat a Count DPC 90 9.0 90 9.0 8.0 8.0 7.0 7.0 Ra atio 6.0 50 5.0 4.0 Ra atio 6.0 50 5.0 4.0 3.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0
Ra atio Siemens ADVIA Centaur 1 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 tio Ra Siemens ADVIA Centaur 1 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0
Ra tio Siemens Immulite 2000 Siemens Immulite 2000 1 1 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Ra atio 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0
Ra atio Roche Cobas (II) 1 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0 Ra atio Roche Cobas (II) 1 90 9.0 8.0 7.0 6.0 50 5.0 4.0 3.0 0.5 1.0 1.5 2.5 3.0 3.5 4.0
FIGURE 1B Abbott Architect i2000 (I) Abbott Architect i2000 (I) 18 1.8 18 1.8 1.6 1.6 Ra atio 0.8 Ra atio 0.8 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4
tio Rat Abbott Architect i2000 (II) 18 1.8 1.6 0.8 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 tio Rat Abbott Architect i2000 (II) 1.8 1.6 0.8 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4
Beckman Coulter Access Beckman Coulter Access 18 1.8 18 1.8 1.6 1.6 Ra atio 0.8 Ra atio 0.8 02 0.2 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4
tio Rat Siemens Coat a Count DPC Siemens Coat a Count DPC 18 1.8 18 1.8 1.6 1.6 0.8 0.8 02 0.2 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Rat tio
Ra atio Siemens ADVIA Centaur 18 1.8 1.6 0.8 02 0.2 Ra atio Siemens ADVIA Centaur 18 1.8 1.6 0.8 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4
tio Ra Siemens Immulite 2000 Siemens Immulite 2000 18 1.8 1.6 0.8 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Ra tio 18 1.8 1.6 0.8 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4
Ra atio Roche Cobas (II) Roche Cobas (II) 18 1.8 18 1.8 1.6 1.6 0.8 0.8 02 0.2 02 0.2 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 4.0 8.0 1 16.0 2 24.0 28.0 3 36.0 4 Ra atio