Norovirus Food-borne Disease and Infectious Gastroenteritis

Transkript

1 December Norovirus Food-borne Disease and Infectious Gastroenteritis Yukinao H6N6H=> Division of Virology, Department of Microbiology, Tokyo Metropolitan Institute of Public Health: 3241 Hyakunin-cho, Shinjuku-ku, Tokyo , Japan food-borne disease; Norovirus; infectious gastroen- Key words: teritis RT-PCR PCR 2. 1) 2) 3) 4) 5) DNA RNA RNA RNA 6) G G G Yukinao_Hayashi@member.metro.tokyo.jp ss()rna G 1976 ss()rna G 1973 dsrna ABC 1975 ss()rna dsdna 4041 : ss ds AC A A nm

2 280 Vol. 51, No (Family) 2. (Genus) (Species) Caliciviridae Norovirus Norwalk virus Sapovirus Sapporo virus Lagovirus Rabbit hemorrhagic disease virus European brown hare syndrome virus Vesivirus Feline calicivirus Vesicular exanthema of swine virus Nebovirus Newbury-1 virus ) / /2008, 2008/

3 December NV () () (50.0) (26.5) (23.1) (21.2) (13.6) (7.4) (12.9) (20.5) (20.0) (50.0) (57.7) (57.6) (81.8) (92.6) (80.6) (69.2) ) /2007, 2007/ 2008, 2008 / / / / / / / / / )

4 282 Vol. 51, No , ) ,000 5,000/ (97.0) ,128 m 3 11,860 m 3 /hr 5.6/hr m 3, 210 m 3 /hr, 0.7/hr , (48.7) G 752 (77.8) G 99 (10.2) G G 65 (6.7) 40 (4.1) A 17 C G25 G ) 5 G 5 G 11 G/4 239 (65.8), G/3 31 G/6 25 G/13 20 G/4 16 G/2 13 G/4 1996

5 December G G G/ (80.7) G/4 5 G/ G/ / 2007 G/ / , 2008/ G/4 G/4 G/2, /3, /6, /13, G/ G/4 9) (viruslike particle; VLP) 2000 VLP ABO Lewis 10) ABO Lewis 8, 9 8 G/4 B 4

6 284 Vol. 51, No. 6 PCR ABO 2 9. Lewis 1 ABO Lewis 8. PCR PCR/LAMP PCR/ PCR ) Kapikian, A. Z., Wyatt, R. G., Dolin, R., Thornhill, T. S., Kalica, A. R., Chanock, R. M. Visualization by immune electron microscopy of a 27 nm particle associated with acute infectious nonbacterial gastroenteritis. J. Virol., 10, (1972). 2) Chiba, S., Sakuma, Y., Kogasaka, R., Akihara, M., Terashima, H., Horino, K., Nakao, T. Fecal shedding of virus in relation to the days of illness in infantile gastroenteritis due to calicivirus. J. Infect. Dis., 142, (1980). 3) Bishop, R. F., Davidson, G. P., Holmes, I. H., Ruck, B. J. Virus particles in epithelial cells of duodenal mucosa from children with viral gastroenteritis. Lancet, 2, (1973). 4) Madeley, C. R., Cosgrove, B. P. 28 nm particles in faeces in infantile gastroenteritis. Lancet, 2, (1975) 5) Flewett, T. H., Bryden, A. S., Davies, H., Morris, C. A. Virus particles in gastroenteritis? Epidemic viral enteritis in a long-stay children s ward. Lancet, 1, 45 (1975). 6) Duizer, E., Schwab, K. J., Neill, F. H., Atmar, R. L., Koopmans, M. P. G., Estes, M. K. Laboratory e#orts to cultivate noroviruses. J. Gen. Virol., 85, 7987 (2004). 7) Kimura, H., Nagano, K., Kimura, N., Shimizu, M., Ueno, Y., Morikane, K., Okabe, N. A norovirus outbreak associated with environmental contamination at a hotel. Epidemiol. Inf. (2010), in press. 8) Kageyama, T., Shinohara, M., Uchida, K., Fukushi, S., Hoshino, F. B., Kojima, S., Takai, R., Oka, T., Takeda, N., Katayama, K. Coexistenca of multiple genotypes, including newly identified genotypes, in outbreaks of gastroenteritis due to Norovirus in Japan. J. Clin. Microbiol., 42, (2004). 9) Jiang, X., Wang, M., Graham, D. Y., Estes, M. K. Expression, self-assembly, and antigenicity of the Norwalk virus capsid protein. J. Virol., 66, (1992). 10) Huang, P., Farkas, T., Marionneau, S., Zhong, W., Ruvoën-Clouet, N., Morrow, A. L., Altaye, M., Pickering, L. K., Newburg, D. S., LePendu, J., Jiang, X. Noroviruses bind to human ABO, Lewis, and secretor histo-blood group antigens: Identification of 4 distinct strain-specific pattern. J. Inf. Dis., 188, 1931 (2003).