Dödsorsaker för män och kvinnor. Riskfaktorer har minskat Förbättrad behandling

Transkript

1 SCAPIS Swedish CArdioPulmonary bioimage Study A national resource for research and one of the biggest programs for research in heart and lung disease

2 Dödsorsaker för män och kvinnor Riskfaktorer har minskat Förbättrad behandling

3 Antal kardiovaskulära dödsfall i relation till uppskattad kardiovaskulär risk (%) Cooney MT 2009

4 SCAPIS outline Identification of vulnerable plaques CTA Ultrasound (carotid artery) ULA-OP or MRI (carotid artery) Visceral adipose tissue, epicardial and liver fat CT Structural changes in lung tissue CT Baseline survey includes: Blood tests Anthropometry Blood pressure, ankle-arm index Physical activity measurement Lung function tests (spirometry and CT) ECG (V-ECG) Detailed questionnaire - Environmental and socioeconomic factors Local and central biobank for blood and urine analyses Follow-up via national registries Morbidity Mortality Research centers at six universities 30,000 men and women aged 50 to 64 years

5 Sequential start transfer of knowledge and experiences to new sites Göteborg Malmö Site 3 Site 4 Site 5 Site 6 Göteborg; Pilot study (n=1111). Full study started okt/nov 2013 Malmö/Lund; Start mars Stockholm; Planned start mars Uppsala/Linköping/Umeå; Planned start fall

6 Studiebas 5000 män och kvinnor per universitetsort år Slumpmässigt valda från befolkningen i Malmö, Göteborg, Stockholm, Uppsala, Umeå, Linköping

7 Core Investigation Göteborg Malmö Medical history Questionnaire Diet questionnaire Blood tests/biobanking blood and urine Anthropometry Lung function tests (spirometry/co-diff) Accelerometry (7 days) Blood pressure/ankle-arm index ECG Ultra sound carotids CT (lungs, heart, body composition) MRI carotids (5-10% of individuals) Microbiotics Fitness bicycle Sleep apnea test Physical self-efficacy test Uric acid (extra blood test) V-ECG Cognitive test (trail making) Cadmium (extra blood test) Optional Creatinine follow-up Impaired Glucose Tolerance Tomosynthesis CT lungs after full expiration Impulsoscillometry (IOS) Echocardiography Orthostatic blood pressure ECG deep breathing Pulse wave analysis Advanced glycated endproducts Nano particle retension test Ultra Sound plaque analysis The Satisfaction with life-test Life orientation test revised Riksmaten

8 Recruitment Letter of invitation Phone call (at least x3) New letter if no contact Scheduled visits Communication activities SCAPIS Malmö/Lund (n=5000, random sample, years) Day 1 Informed consent -Blood and urine -Biobanking Analysis of lipids, creatinin, Glc, HbA1c, RBC, WBC, diff Questionnaire Diet questionnaire Anthropometry Accelerometry (7 days) Day 2 Ankle-arm index ECG 5 min+deep breathing Orthostatism Pulse wave analysis AGE-reader Ultrasound carotids Spirometry Impulsoscillometry Nano particle retention Day 3 CT-thorax + CT expiration CT-Angio CT-body composition Echocardiography

9 Coronary computed tomography angiography (CTA) Development Radiation Dual energy Limitations Radiation Contrast Calcifications SCAPIS chose Siemens Somatom definition flash

10 Type of biological sample Tubes/donor N of aliquotes National resource 4 ml EDTA whole blod Biobanking for DNAextraction 2 (primary tubes are biobanked) 2 1 8,5 ml EDTA whole blood gel Biobanking of EDTA-plasma ,5 ml serum with gel Biobanking of serum ,0 ml Li-Hep with gel Biobanking of Li-Heparinplasma ,0 ml Na-Citrate 3,2% Biobanking av citrate plasma Urine Biobanking of urine Faeces Biobanking of microbiota 1

11 Nationell struktur för SCAPIS Legalt säte vid Göteborgs universitet Avtal mellan universitet beträffande tillgång till data Styrgrupp: Göran Bergström (chair), Annika Rosengren, Gunnar Engström, Olle Melander, Carl Johan Östgren, Jan Engvall, Stefan Söderberg, Anette Sandström, Tomas Jernberg, Kerstin Cederlund, Lars Lind, Johan Sundström Sponsor: Hjärt- Lungfonden (Bim Boberg) Projektledare: Sven Anders Benjegård Projektgrupper för CT Lunga Hjärta Kost Biobank SAB Ulf de Faire Anders Waldenström Göran Berglund Claes-Göran Löfdahl Juhani Knuti, Finland Robert Clark, UK Marc Dewey, Germany Marike Boezen, Netherlands Eva Prescott, Denmark Kay-Thee Khaw, UK

12 SCAPIS Malmö/Lund Projektledare Margaretha Persson Gunnar Engström, PI; Olle Melander co-pi Screening-grupp Margaretha Persson Gerd Östling Biobank/prover Margaretha Persson Joyce Carlson Gunilla Nordin- Fredriksson Klinisk uppföljning Klas Gränsbo Olle Melander Klin fys/ EKG/Spiro/sph: Per Wollmer Kardiologi David Erlinge Martin Magnusson CT-grupp Hanna Markstad Ellen Ostenfeld Lisa Ander Olsson Olle Ekberg Lars Bååth Ultraljud/kärl/MR Gerd Östling Isabel Goncalves Anders Gottsäter Lunggrupp Eeva Piitulainen Arne Egesten Senior advisors Bo Hedblad Peter Nilsson

13 Acknowledgements Hjärt-Lungfonden Knut och Alice Wallenbergs stiftelse Vetenskapsrådet VINNOVA Region Skåne BBMRI Lunds Universitet

14 Prediction is very difficult, especially about the future

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