Nasrin Perskvist, National Coordinator and Director of Clinical Cytology Biobank BBMRI.se Karolinska Institute, Inst LabMed Karolinska University

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1 , National Coordinator and Director of Clinical Cytology Biobank BBMRI.se Karolinska Institute, Inst LabMed Karolinska University Hospital Clinical Pathology Cytology

2 BBMRI.se Karolinsk Institut Karolinska University hospital This is the outcome of a wonderful and synergic cooperation

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4 Örebro Umeå Göteborg Karolinska BBMRI.se Biobanking and Molecular Resource Infrastructure of Sweden Östersund Sunderby Umeå Sundsvall Average handled 65% of the total cell samples in the country annually At present the total number of biobanked Gynecological cell samples on a common platform and nation wide is cell samples. : Project leader for development of Cytology Biobank National Coordinator Director of the Cytology Biobank at Karolinska, Headquarter Göteborg Falun Örebro Karlstad Linköping Lund Gävle Västerås Stockholm

5 Process of Moving of the biobank from regionally to Nation wide August 2011; Inauguration of the Cytology Biobank at Karolinska Stockholm (Start date) Summer 2012; Purchase the second biobank system and implemented at the site of Karolinska Autumn 2012; Lancing and Implementation of the Biobank at site of Sahlgrenska Hospital in Göteborg Contact person: Joakim Dillner and Karolinska University Hospital Contact person: Joakim Dillner Karolinska University Hospital Contact person: Peter Horal and Katarina Johansson Clinical Mikrobiolog Departement at Sahlgrenska Spring 2013; Upgrading entire sample handling system of the biobank nation wide- At the Headquarter-Karolinska Spring 2013; Lancing and implantation of the Cytology Biobank at the site of Örebro University Hospital Contact person: Karolinska University Hospital Contact person: Mats Karlsson and Helena Issaksson Laboratory Medicine, Örebro Hospital

6 Process of Moving of the biobank from regionally to Nation wide Autumn 2013; Lancing and implantation of the Cytology Biobank at the site of Umeå University Hospital Contact person: Gun Jakobsson, Marko Korpela, Anna Knuts Noudot Laboratoriemedicin, Norrlands Universitetssjukhuset, Umeå Autumn 2014; Agreement of lancing second Biobank system at site of Sahlgrenska Hospital in Göteborg. February 2015 implemented, ready in Routine Winter 2014; Agreement of lancing second Biobank system at site of Umeå University Hospital Mars 2015 Implemented and ready in Routine Contact person: Peter Horal and Katarina Johansson Clinical Mikrobiolog Departement at Sahlgrenska Contact person: Gun Jakobsson, Marko Korpela, Anna Knuts Noudot Laboratoriemedicin, Norrlands Universitetssjukhuset, Umeå

7 The biobank s activities during 2014 and onward Studienamn (Fenotyp) Utvärdering av falskt negativa i HPV primärscreeningen. Genotypning av HPV för klinisk handläggning Förekomst av högrisk HPV på lagrade LBC-prover RT-Långförvaringseffekt på LBC-prover innan biobankning Kvalitetskontrol av lagrade LBC-prover för HPV Kvalitetskontroll av lagrade LBC-prover för morfologisk diagnostik Validering av diagnostik kit för Ki67 och p16 Genetiska studier av hemofagocyterande lymfohistiocytos i association med malignitet Biobanksbaserad studie av biomarkörer för livmoderhalscancer Ansvarig forskare (hemort) Anders Hjerpe Karolinska sjukhuset Kristina Elfgren Kvinnokliniken, Karolinska sjukhuset Ingrid Norman, Klinisk Cytologi, Karolinska sjukhuset Cytologibiobank Karolinska Sjukhuset Cytologibiobank Karolinska Sjukhuset Cytologibiobank Karolinska Sjukhuset Roche Ventana Stockholm- Sverige Jan-Inge Henter och Marie Meets, Barncancerforskningsenheten, Karolinska sjukhuset och KI biobank Joakim Dillner Karolinska sjukhuset Antal ingående biobankad cellprover Start datum (slutdatum) ( ) ( ) Prediktion av Kvinnocancer med OMICS teknik att individualisera screening och prevention Prof Martin Widschwendter, University College London Bio/Medicinska utbildningar 2013Framåt Kontinuerligt Kontinuerligt BMA-Sjuksköterskeutbildning Cytologibiobank Karolinska Sjukhuset Klinisk omdiagnostisering 2013 framåt Klinisk Patologi-Cytologi Kontinuerligt Kontinuerligt

8 Financial income (intäkter) of the Cytology Biobank to SLL and BBMRI.se 2014 and onward subsidized requisition from Sahlgrenska to BBMRI.se subsidized requisition from Umeå Hospital to BBMRI.se 50% of total sum 50% of total sum Financial Income from research groups provided by Cytology Biobank Financial income from the KI-university education of Nursing and BMA provided academic courses by Cytology Biobank

9 Cytology Biobank activities updated Vital to connect together Clinical Cytological Laboratories Nation Wide Autumn 2011 April 2012 Spring 2012 Spring 2013 Autumn 2013 Winter 2014 Autumn 2015 Autumn 2015 Nationell Cytologibiobank 1:a Nationell Hearing Nordic BBMRI WP3 meeting: Clinical Biobanking in the Nordic Countries First User Meeting (Användarmöte)Karolinska Nationell Cytologibiobank 2:a Nationell Hearing Second User Meeting, Göteborg Third User Meeting, Karolinska 3:a Nationell Hearing Forth User Meeting, Karolinska Connection of laboratories

10 Nation Wide Connection Between Laboratories Östersund Sunderby Umeå Sundsvall Falun Gävle Västerås Örebro Karlstad Stockholm Göteborg Linköping Lund

11 Systematic Biobanking in Clinical Laboratory Medicine Clinical Chemistry Clinical Microbiology Clinical Immunology Clinical Pharmacology Clinical Lab-Med Clinical Pathology Clinical Virology Clinical Cytology Clinical Genetic The Stat-of-Art in Clinical Laboratory Medicine in Health Care System