Occupational and Environmental Medicine, Lund University Hospital, SE Lund, Sweden

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1 Curriculum vitae Name Maria Hedmer Date of Birth February 9, 1975 Affiliation Occupational and Environmental Medicine, Lund University Hospital, SE Lund, Academic Degrees 2006 Doctor in Medical Sciences, Lund University, Thesis: Monitoring of occupational exposure to antineoplastic drugs 2000 Master of Science in Chemistry, Lund University, Academic Studies and Scientific Conferences 2012 Aerosols 2012, April 2012, Lund,. Occupational and Environmental Spring meeting, 8-10 May 2012, Umeå,. 7th International Conference on the Science of Exposure Assessment (X2012) 2-5 July 2012, Edinburgh, Scotland Nanomaterial possiblities and risks, Toxicological Council, Stockholm, Airmon The 7 th International Symposium on Modern Principles for Air Monitoring and Biomonitoring June 2011 in Loen, Norway. NIVA Workshop: Exposure to incidentally formed and engineered nanoparticles. Is there any difference in health effects? Loen, Norway. Case methodology, MedCul, Lund University, 7-21 September 2011, Lund,. 55th Nordic Work Environment Meeting (NAM), October 2011, Lund, Nordic Tour 2010: Health effects and risks of nanoparticles, Nordic Institute for Advanced Training in Occupational Health (NIVA), Copenhagen, Denmark 2008 Safety and Risks of Nanotechnologies and Nanoparticles to Workers and Citizens, Nordic Institute for Advanced Training in Occupational Health (NIVA), Kgs. Lyngby, Denmark 2007 Occupational and Environmental Spring meeting, April, Lund,. Course in Incident and risk analysis (1,5 days), Lund University Hospital, th Annual Metting of the Environmental Mutagen Scociety, Prague, Czech Republic Surveillance and diagnosis of hand arm vibration syndrome according to the EU directive (one-day course at Sahlgrenska Academy, Göteborg University) Göteborg, Hälsofrämjande sjukhus :e nationella konferensen oktober 2006, Malmö, Sverige Nanotoxicity Potential Risks and Safety Assessments, Karolinska Institutet & Swedish Society of Toxicology, Stockholm, 2005 The Annual General Meeting of the Swedish Society of Medicine, Stockholm, 51 st Nordic Work Environment Meeting, Ängelholm, 2004 Human Exposure Assessment 5p, Umeå University, Aerosol technology 5p, Ergonomics & Aerosol Technology, LTH, Sixth International Symposium on Biological Monitoring in Occupational & Environmental Health, Heidelberg, Germany Danish NIOH symposium on occupational health risks: WOOD DUST, Copenhagen Denmark 2003 The Electronic Library (PhD course at the Medical Faculty at Lund University), Lund, Statistical Methods for Medical Research (PhD course at the Medical Faculty at Lund

2 University), Lund, Research ethics (PhD course at the Medical Faculty at Lund University), Lund, Basic Pharmacokinetics 2p, University of Manchester, UK The Annual General Meeting of the Swedish Society of Medicine, Stockholm, 2002 Environmental Toxicology 5p, Lund University, Oral communication (PhD course at the Medical Faculty at Lund University), Lund, 2001 Physiology 3p, Center for Chemistry and Chemical Engineering, LTH, Lund, 2000 Occupational and Environmental Medicine 2p, Medical Faculty at Lund University, Professional Appointments Occupational Hygenist, Occupational and Environmental Medicine, Lund University Hospital, PhD student, Department of Occupational and Environmental Medicine, Lund University, Research Engineer, Department of Occupational and Environmental Medicine, Lund University, 2000 Laboratory administator, AstraZeneca, Lund, Scientific Assignments Reviewer for International Archives of Occupational and Environmental Health Reviewer for Toxicological Letters Reviewer for Rapid Communication in Mass Spectrometry Reviewer for Annals of Occupational Hygiene Other merits Seminarleader at the course in Occupational and Environmental medicine for students in medicine, Faculty of Medicine, Lund University, Lecturer at the course Environmental Measurement Techniques FKF Supervisor at the course Occupational health nurses project work 5 p, Faculty of Medicine, Lund University, 2004 Supervisor at the course Risk Analysis in Environment and Public Health 10p, Faculty of Science, Lund University, Publications Thesis 2006 Doctor in Medical Science, Division of Occupational and Environmental Medicine and Psychiatric Epidemiology, Lund University,. Monitoring of occupational exposure to antineoplastic drugs. Original peer-reviewed publications 1. Hedmer M, Jönsson BAG and Nygren O. Development and validation of methods for environmental monitoring of cyclophosphamide in workplaces. Journal of Environmental Monitoring 2004;6: Hedmer M, Georgiadi A, Rämme E, Eksborg S, Jönsson BAG, Ehrsson H. Surface contamination of cyclophosphamide packaging and surface contamination with antineoplastic drugs in a hospital pharmacy in. Annals of Occupational Hygiene 2005;49:629.

3 3. Hedmer M, Höglund P, Cavallin-Ståhl E, Albin M and Jönsson BAG. Validation of urinary excretion of cyclophosphamide as a biomarker by studying its renal clearance at high and low plasma concentrations in cancer patients. Int Arch Occup Environ Health. 2008;81: Hedmer M, Tinnerberg H, Axmon A and Jönsson BAG. Environmental and biological monitoring of antineoplastic drugs in four workplaces in a Swedish hospital. Int Arch Occup Environ Health 2008; 81: Hedmer M, Wohlfart G. Hygienic guidance values for wipe sampling of antineoplastic drugs in Swedish hospitals. Journal of Environmental Monitoring 2012;14: Nilsson J, Hedmer M, Lundh T, Nilsson L, Skerfving S, Bergdahl IA. Investigastion of lead concentrations in whole blood, plasma and unrine as biomarkers for biological monitoring of lead exposure. Submitted to Journal of Exposure Science and Environmental Epidemiology Abstracts 1. Hedmer M, Cavallin-Ståhl E, Höglund P, Jönsson BAG. Cyklofosfamid (CP) i urin vid riskvärdering vid cytostatikaarbete. Svenska Läkaresällskapets Riksstämma november 2003, Stockholm. Hygiea 2003; 112: Hedmer M, Jönsson BAG. Analytical methods for biologcial monitoring of cyclophosphamide in urine and in plasma. Sixth International Symposium on Biological Monitoring in Occupational & Environmental Health, Heidelberg, Germany, Sept 6-8, 2004, p Hedmer M, Jönsson B. Metod för provtagning av cytostatikakontaminerade ytor samt tillämpning i beredningscentral för cytostatika. Nordiska Arbetsmiljömötet, Sverige, augusti p Hedmer M, Tinnerberg H, Jönsson B. Kontamination av cytostatika på golvytor på onkologisk dagvårdsavdelning. Svenska Läkaresällskapets Riksstämma 30 november- 2 december 2005, Stockholm. Hygiea 2005; 114: Hedmer M, Höglund P, Albin M, Jönsson BAG. Validation of urinary excretion of cyclophosphamide as a biomarker by studying its renal clearance at high and low plasma concentrations in cancer patients. 36 th Annual Metting of the Environmental Mutagen Scociety, Prague, Czech Republic, July 2-6, Hedmer M. Kartläggning av exponering för cytostatika för sjukhuspersonal: effekt i form av nya rutiner och minskad exponering. Hälsofrämjande sjukhus :e nationella konferensen oktober 2006, Malmö, Sverige. 7. Tinnerberg H, Hedmer M. Hygiene In High Tech Industry Don t Forget The Traditional Industry. IOHA 7th International scientific conference, 18-22/2 2008, Taipei, Taiwan. 8. Hedmer M. Surface monitoring of antineoplastic drugs in Swedish hospitals and hygienic guidance values. Airmon, Loen, Norway, June 19-23, Hedmer M, Wohlfart G. Hygienic guidance values for surface monitoring of antineoplastic drugs in Swedish hospitals. 55th Nordic Work Environment Meeting (NAM), 17 October 19 October 2011, Lund,. 10. Albin M, Bohgard M, Hedmer M, Gustavsson P, Kanje M, Rissler J. Risk assessment for Carbon nanotubes. 55th Nordic Work Environment Meeting (NAM), 17 October 19 October 2011, Lund,. 11. Albin M, Bohgard M, Hedmer M, Gustavsson P, Kanje M, Rissler J. Risk assessment for Carbon nanotubes. Ramazzini Days 2011, October 2011, Carpi, Italy. 12. Nilsson PT, Eriksson AC, Messing M, Isaxon C, Hedmer M, Tinnerberg H, Meuller B, Svensson CR, Deppert K, Bohgard M, Pagels J. Soot Particle-AMS for time and composition resolved detection of engineered metal particles. Nordic Society for Aerosol Research (NOSA) November 2011, Tampere, Finland. 13. Ludvigsson L, Isaxon C, Nilsson P T, Messing M E, Tinnerberg H, Hedmer M, Pagels J. Emissions of arc discharge produced multi-walled carbon nanotubes in an industrial environment. Aerosols 2012, April 2012, Lund,.

4 14. Hedmer M, Isaxon C, Nilsson PT, Eriksson AC, Messing ME, Tinnerberg H, Pagels J. Occupational hygiene and stationary emission measurements of engineered nanoparticles during cleaning operations in a clean room laboratory. 7th International Conference on the Science of Exposure Assessment (X2012) 2-5 July 2012, Edinburgh, Scotland. 15. Nilsson PT, Eriksson AC, Messing ME, Isaxon C, Hedmer M, Tinnerberg H, Meuller BO, Svensson CR, Deppert K, Bohgard M, Pagels J. Laser Vaporizer-AMS for exposure assessment and detection of airborne engineered metal nanoparticles. European Aerosol Conference 2012, 2-7 September, Grenada, Spain. 16. Hedmer M, Isaxon C, Nilsson P T, Ludvigsson L, Messing M E, Skaug V, Tinnerberg H, Pagels J. Measurements of exposure and emission of arc discharge produced multi-walled carbon nanotubes in a small scale facility. SENN International Congress on Safety of Engineered Nanoparticles and Nanotechnologies October, Helsinki, Finland. Reports 1. Bech J, Lund Nielsen B, Wolff C, Gyntelberg F, Hedmer M. Cytostatikamålinger i Finsencentret Rigshospitalet november/december Rapport i samarbete mellan Finsencentret, Arbejds- Miljømedicinsk klinik, Bispebjerg hospital och Yrkes- och miljömedicin, Universitetssjukhuset i Lund mars Hedmer M. Kartläggning av cytostatikakontamination på ytor - en studie utförd på fem sjukhus i Södra Sjukvårdsregionen. Rapport 2008, Arbets- och miljömedicin, Lund. 3. Hedmer M. Exponeringsmätning, med fokus på oorganiskt damm och respirabelt kvartsdamm, på ett byggföretag som arbetar med sprutputsning. Rapport 2009, Arbets- och miljömedicin, Lund. 4. Gustavsson P, Hedmer M, Rissler J. Kunskapsöversikt: Kolnanorör - Exponering, toxikologi och skyddsåtgärder i arbetsmiljön. Rapport 2011:1, Arbetsmiljöverket, Stockholm. 5. Hedmer M. Exponeringsmätningar, med fokus på respirabelt metalldamm, på svetsföretag i Södra Sjukvårdsregionen. Rapport 27/2011, Arbets- och miljömedicin, Lund. 6. Hedmer M. Pilotstudie: Exponeringsmätningar av dieselavgaser på företag i Södra Sjukvårdsregionen. Rapport 37/2011, Arbets- och miljömedicin, Lund. 7. Hedmer M. Exponeringsmätningar av respirabelt damm och ultrafina partiklar på livsmedelslager i Södra Sjukvårdsregionen. Rapport 38/2011, Arbets- och miljömedicin, Lund. 8. Hedmer M, Kåredal M, Gustavsson P, Rissler J. The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. XXX. Carbon nanotubes. Arbete & Hälsa 201x (manuscript) Other publications 1. Hedmer M. Interindividuella skillnader i blymetabolism hos blyarbetare. Bulletin. Yrkes- o miljömed klin. Lunds Universitetssjukhus, Lund. 2001;1: Hedmer M. Cyklofosfamid mätmetoder. Bulletin. Yrkes- o miljömed klin. Lunds Universitetssjukhus, Lund. 2003;2: Hedmer M. Cyklofosfamid i urin: Hur ser utsöndringen ut? Bulletin. Yrkes- o miljömed klin. Lunds Universitetssjukhus, Lund. 2003;2:7. 4. Hedmer M. Cytostatikakontaminerad arbetsmiljö på sjukhusapotek? Bulletin. Yrkes- o miljömed klin. Lunds Universitetssjukhus, Lund. 2004;1: Hedmer M. Trädamm Symposium. Bulletin. Yrkes- o miljömed klin. Lunds Universitetssjukhus, Lund. 2004;2: Georgiadi A, Eksborg S, Hedmer M. Låga mängder av cyklofosfamid och ifsofamid på ingående förpackningar av Sendoxan. Sjukhusfarmaci 2004;3: Hedmer M, Georgiadi A, Eksborg S. Små mängder av cyklofosfamid och ifosfamid på läkemedelsförpackningar. Bulletin. Yrkes- o miljömed klin. Lunds Universitetssjukhus, Lund. 2005;1:9. 8. Hedmer M. Stora brister inom steindustrin när det gäller kvartshaltigt damm. Bulletin. AMM, Lund, 2006;3:4.

5 9. Hedmer M. Cytostatikakontamination på sjukhus i södra Sverige. Bulletin. AMM, Lund, 2008;4: Hedmer M. Putsade väggar modernt men dammigt. Bulletin. AMM, Lund, 2010;1: Hedmer M, Gustavsson P, Rissler J. Kolnanorör exponering, toxikologi och skyddsåtgärder i arbetsmiljön. Bulletin. AMM, Lund, 2011;2: Hedmer M, Gustavsson P, Rissler J. Kolnanorör exponering, toxikologi och skyddsåtgärder i arbetsmiljön. SYMFs medelemsblad, 2011;1:6 13. Hedmer M, Gustavsson P, Rissler J. Kolnanorör exponering, toxikologi och skyddsåtgärder i arbetsmiljön. FTF Arbetsmiljö, 2011:3: Hedmer M. Att mäta luftföroreningar i arbetsmiljön. Bulletin. AMM, Lund, 2012;2: Albin M, Hedmer M. Koll på kvarts. Bulletin. AMM, Lund, 2012;2:13. Other Merits / Information of Relevance I am a board member of the Swedish Association of Occupational and Environmental Hygiene, 2011-