Grundutbildning/AT-läkareutbildning vid lasarettet i Lidköping (Obstetrik/gynekologi, medicin, kirugi, anästesiologi, psykiatri)

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1 MERIT OCH TJÄNSTFÖRTECKNING Jørn E. S. Nielsen Lägeeksamen vid Københavns Universitet Autorisation til selvständigt virke som läge. Sundhedsstyrelsen i Danmark Autorisation til virksomhed som almen praktiserande läge (Kurs vid Århus Universitet). Sundhedsstyrelsen i Danmark Svensk legitimerad läkare Specialistkompetens i yrkesmedicin och i allmän internmedicin Doktor i Medicinsk Vetenskap på avhandlingen Airways Effects in Workers Exposed to Organic Acid Anhydrides Lunds Universitet Grundutbildning/AT-läkareutbildning vid lasarettet i Lidköping (Obstetrik/gynekologi, medicin, kirugi, anästesiologi, psykiatri) Specialistutbildning i allmän internmedicin: Medicinkliniken i Lidköping juni 1977 till mars 1979 Medicinkliniken, Malmö Allmänna Sjukhus från mars 1979 till november 1980.St Lars Sjukhus, psykiatri november 1980 till februari Specialistutbildning i yrkesmedicin: Yrkesmedicinska kliniken i Lund (underläkara, klinisk amanuens) februari 1981 till juni Avdelningsläkare vid Yrkes och miljömedicinska kliniken, Lund Biträdande överläkare ss. från Överläkare/chef för den yrkesmedicinska sektionen ss Överläkare/chef för luftvägssektionen/senior medical doctor/head of section ss 2002 Docent/associate professor i Yrkes- och miljömedicin vid Lunds Universitet VETENSKAPLIGT ARBETE/SCIENTIFIC PUBLICATIONS Organiska syraanhydrider/organic acid anhydrides Wernfors M, Nielsen J, Schütz A, Skerfving S. Phthalic Anhydride-Induced Occupational Asthma. Int. Archs Allergy appl Immun 1986;79: Nielsen J, Welinder H, Schütz A, Skerfving S. Specific serum antibodies against phthalic anhydride in occupationally exposed subjects. J Allergy Clin. Immunol.1988; 82: Nielsen J, Welinder H, Skerfving S. Allergic airway disease caused by methyl tetrahydrophthalic anhydride in epoxy resin. Scand J Work Environ Health 1989; 15: Welinder H, Nielsen J, Gustavsson C, Bensryd I, Skerfving S. Specific antibodies to methyltetrahydrophthalic anhydride in exposed workers. Clinical and Experimental Allergy 1990; 20: Nielsen J, Bensryd I, Almquist H, Dahlqvist M, Welinder H, Alexandersson R, Skerfving S. Serum IgE and lungfunction in workers exposed to phthalic anhydride. Int Arch Occup Environ Health 1991; 63:

2 Welinder H, Nielsen J. Immunologic tests of specific antibodies to organic acid anhydrides. Allergy 1991; 46: Nielsen J, Welinder H, Horstmann, Skerfving S. Allergy versus methyltetrahydrophthalic anhydride in epoxy resin workers. British Journal of Industrial medicine 1992;49: Jönsson B, Welinder H, Nielsen J. Hexahydrophthalic anhydride (HHPA): Bronchial, nasal, and conjunctival provocation tests in controlled standard atmospheres. Allergy supplement 1992; 47: 139. (abstract; XV th congress of the European Academy of Allergology and Clinical Immunology Paris; may 1992). Nielsen J, Welinder H, Ottosson H, Bensryd I, Venge P, Skerfving S. Nasal challenge shows pathogenetic relevance of specific IgE serum antibodies for nasal symptoms caused by hexahydrophthalic anhydride. Clinical and Experimental Allergy 1994; 24: Nielsen J, Welinder H, Bensryd I, Skerfving S. Symptoms and immunological markers induced by exposure to methyltetrahydrophthalic anhydride. Allergy 1994; 49: Welinder E H, Jönsson BAG, Nielsen J, Ottosson HE, Gustavsson CA. Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride in exposed workers. Scand J Work Environ Health. 1994; 20: Nielsen J, Jonsson U, Welinder H, Bensryd I, Rylander L, Skerfving S. HLA phenotype related to immune nonresponsiveness in workers exposed to organic acid anhydrides. J Occup Environ Med 1996; 38: Nielsen J, Welinder H, Jönsson B, Bensryd I, Skerfving S. Arbetsrelaterad näsblödning hos arbetare exponerade för organiska syraanhydrider. Svenska Läkaresälskapets Riksstämma november 1997.Hygiea 1997;106:120. Welinder H, Nielsen J, Bensryd I, Björk B, Strömberg U, Skerfving S. Decline in serum antibodies to methyltetrahydrophthalic anhydride after cessation of exposure. Implications for use as a biomarker. Biomarkers 1998; 2: Drexler H, Schaller K-H, Nielsen J, Weber A, Weihrauch M, Welinder H, Skerfving S. Efficacy of measures of hygiene in workers sensitised to acid anhydrides and the influence of selection bias on the results. Occup Environ Med 1999; 56: Drexler H, Jönsson BAG, Göen Th, Nielsen J, Lakemeyer M, Welinder H. Exposure assessment and sensitisation in workers exposed to organic acid anhydrides. Int Arch Occup Environ Health 2000; 73: Jones MG, Welch J, Nielsen J, Bensryd I, Welinder H, Venables K, Welsh K, Newman taylor AJ. The association of HLA-DR1 and HLA-DQ5 with sensitisation to inhaled acid anhydrides. American Thoracic Society Rosqvist S, Nielsen J, Welinder H, Rylander L, Jönsson BAG. Exposure-response relationship of hexahydrophthalic anhydride using total plasma protein adducts as index of long-term exposure. In: Hagberg M, Knave B, Lillienberg L, Westberg H, editors. X2001 Exposure assessment in epidemiology and practice. Arbete och hälsa 2001(10): Welinder H, Nielsen J, Rylander L, Ståhlbom B. A prospective study of the relationship between exposure and specific antibodies in workers exposed to organic acid anhydrides. Allergy 2001;56:

3 Nielsen J, Welinder H, Jonsson BAG, Axmon A, Rylander L, Skerfving S. Exposure to hexahydrophthalic and methylhexahydrophthalic anhydrides sensitisation and airways effects. Scand J Work Environ Health 2001;27(5): Rosqvist S, Nielsen J, Welinder H, Rylander L, Lindh CH, Jonsson BA.Exposure-response relationships for hexahydrophthalic and methylhexahydrophthalic anhydrides with total plasma protein adducts as biomarkers. Scand J Work Environ Health Aug;29(4): Johannesson G, Lindh C, Nielsen J, Björk B, Rosqvist S, Jönsson BAG. In vivo conjugation of nasal lavage proteins by hexahydrophthalic anhydride. Toxicology and Applied Pharmacology 2004; 194: Jones MG, Nielsen J, Welch J, Harris J, Welinder H, Bensryd I, Skerfving S, Welsh K, Venables KM, Taylor AN. Association of HLA-DQ5 and KLA-DR1 with sensitization to organic acid anhydrides. Clin Exp Allergy 2004; 34: Nielsen J, Welinder H, Bensryd I, Rylander L. Skerfving S. Ocular and airways symptoms related to organic acid anhydrides A prospective study. Allergy 2006;61: Jeppsson M C, Lindh C H, Kristiansson M H, Nielsen J, Jönsson B A G. Methylhexahydrophthalic anhydride adducted albumin tryptic peptides in nasal lavage fluid. Inhalation Toxicology 2009;21: Isocyanater/Isocyanates Nielsen J, Sangö C, Winroth G, Hallberg T, Skerfving S. Systemic reactions associated with polyisocyanate exposure. Scand J Work Environ Health 1985; 11: Sangö C, Nielsen J, Skerfving S, Skarping G. Authors reply. Scand J Work Environ Health 1985; 11: 498. Welinder H, Nielsen J, Bensryd I, Skerfving S. IgG antibodies against polyisocyanates in car painters. Clinical Allergy 1988;18: Brorson T, Skarping G, Nielsen J. Biological monitoring of isocyanates and related amines-test chamber exposure of humans to 1,6- hexamethylenediisocyanate (HDI). Int Arch Occup Environ Health 1990; 62: Polyvinylklorid bearbetning m.m./polyvinylchloride processing Nielsen J, Skerfving S, Åkesson B. Astma vid exponering för en polyfunktionell aziridinhärdare1983. Hygiea band 92 häfte 8: (abstract, Svenska Läkaresällskapets Riksstämma 1983). Nielsen J, Åkesson B, Skerfving S.Phthalate Ester Exposure-Air Levels and Health of Workers Processing Polyvinylchloride. Am. Ind. Hyg. Assoc. J. 1985; 46: Nielsen J, Fåhraeus C, Bensryd I, Åkesson B, Welinder H, Linden K, Skerfving S. Small airways function in workers processing polyvinylchloride. Int Arch Occup Environ Health 1989; 61: Hagmar L, Åkesson B, Nielsen J, Andersson C, Linden K, Attewell R, Möller T. Mortality and Cancer Morbidity in Workers Exposed to Low Levels of Vinyl Chloride Monomer at a Polyvinyl Chloride Processing Plant. Am J Ind Med 1990;17:

4 Effekter av luftföroreningar/ambient air pollution, effects of Timonen KL, Nielsen J, Schwartz J,Gotti A, Vondra V, Gratziou C, Giäver P, Roemer W, Brunekreef B. Chronic respiratory symptoms, skin prick test results and lung function as predictors of peak flow variability. Am J Respir Crit Care Med 1997; 156: Forsberg B, Skerfving S, Welinder H, Nielsen J, Segerstedt B, Mårtensson M-B. Akuta effekter av luftföroreningar på barn med astma. Slutrapport från projektområdet Miljö och Folkhälsa. Red: B-M Bäcklin, A Tuvander. Rapport 4904 från naturvårdsverket s: ISBN Skerfving S, Forsberg B, Welinder H, Nielsen J, Mårtensson M-B. Akuta effekter av korttidsvariationer i luftföroreningsexponering på barn med kronisk luftvägssjukdom. Slutrapport från projektområdet Miljö och Folkhälsa. Red: B-M Bäcklin, A Tuvander. Rapport 4904 från naturvårdsverket s: ISBN Nielsen J, Welinder H, Bensryd I, Mårtensson MB, Skerfving S, Hoek G. Acute respiratory symptoms, medication, and lungfunction in relation to air pollution in children with chronic respiratory symptoms from urban and rural locations in Southern Sweden. Eur Resp Rev 1998; Mårtensson M-B, Welinder H, Nielsen J, Högstedt B, Holmen A, Forsberg B, Skerfving S. Luftföroreningar inne och ute samt luftvägssymptom hos barn i Båstad och Laholm. Allergistämma 1998, 4-5 februari Norra latin, Stockholm. Tema: Olikhet i hälsa. Willers S, Feyerabend C, Nielsen J, Skarping G, Skerfving S. Assessment of environmental tobacco smoke exposure in children with asthmatic symptoms by questionnaire and cotinine concentrations in plasma, saliva and urine. J Clin Epidemiol 2000;53: Timonen KL, Schwartz J, Nielsen J, Brunekreef B. Associations between markers of respiratory morbidity in European children. Eur Respir J 2002;19: Larsson K, Stroh E, Pilesjö, Welinder H, Axmon A, Strömberg U, Nielsen J, Assarsson E. GIS för analys av hälsopåverkan från luftföroreningar. Slutrapport från projektet En studie av självrapporterade besvär i Växjö inom Energimyndighetens Biobränsle Hälsa Miljö. Energimyndigheten. Järvholm B, Forsberg B, Modig L, Nielsen J, Boman K, Jansson K-K. Samband mellan förbränningsrelaterade luftföroreningar och riskindikatorer för hjärt-kärlsjukdom? En panelstudie kopplad till mätkampanjen i Växjö inom Biobränsle Hälsa Miljö. Energimyndigheten Verkstadsmiljö - Svetsrök och andra irritanter/workshops - welding fume, irritants Nielsen J, Dahlqvist M, Welinder H, Alexandersson R, Skerfving S. Small airways function at arcwelding in aluminium. Int Arch Occup Environ Health 1993;65: Simonsson BG. Nielsen J, Karlsson S_E, Horstman V, Kronholm-Diab K, Skerfving S. A prospective study on bronchial responsiveness in newly employed workers exposed to substances potentially harnfull to airways. Eur Resp J 1995; 8(S19):194. Blomqvist A, Duzakin-Nystedt M, Ohlson CG, Andersson L, Jönsson B, Nielsen J, Welinder H. Airways symptoms, immunological response and exposure in powder painting. Int Arch Occup Environ Health 2005; 78: Bohgard M, Nielsen J, Tinnerberg H, Hagerman I, Berglund M, Swietlicki E, Gudmunsson A, Pagels J, Löndahl J, Nilsson E, Deppert K. Methodology for studies on respiratory and cardiovascular effects

5 of humans at occupational exposure to airborne nanoparticles. International Aerosol Conference 2006; St Paul, USA: Karlsson J-E, Nysted M, Tinnerberg H, Nielsen J. Exponeringsnivåer hos svetsare. Svenska läkaresälskapets riksstämma 29 november till 1 december Hygiea 115: Axelsson J, Nielsen J. Luftvägsbesvär bland arbetare exponerade för kaliumaluminiumtetrafluorid. Svenska läkaresälskapets riksstämma 29 november till 1 december Hygiea 115: Larsson B, Karlsson J-E, Nielsen J. Respiratory and ocular symptoms in workers exposed to potassium aluminium-tetrafluoride soldering flux. Int Arch Occup Environ Health 2007;80: Isaxon C, Pagels J, Gudmundsson A, Bohgard M, Asbach C, John AC, Kuhlbusch TAJ, Karlsson JE, Kammer R, Tinnerberg H, Nielsen J. Characteristics of welding fume aerosol investigated in three Swedish Workshops. Inhaled particles X Conference, Manchester, UK Abstract. Asbach C, John AC, Pagels J, Isaxon C, Gudmundsson A, Karlsson JE, Tinnerberg H, Nielsen J, Kuhlbusch TAJ, Bohgard M. Particle size distribution and surface area concentration in welding fumes measured in real workplaces with high time resolution. European Aerosol Conference, Thessaloniki, Greece Abstract. Isaxon C, Pagels J, Gudmundsson A, Asbach C, John A, Kuhlbusch TAJ, Karlsson JE, Tinnerberg H, Kammer R, Nielsen J, Bohgard M. Welding fume generation for controlled human exposures studies in chamber Comparison with detailed work place measurements. European Aerosol Conference, Thessaloniki, Greece Abstract. Jönsson L S, Olsson E, Paulsson K, Nielsen J, Broberg K. Microarray analysis of induced sputum from welders. Abstract ICOH Jönsson BAG, LS Jönsson LS, Nielsen J. Do fatty acid amides have a protective effect against welding fumes? ICOH Abstract Isaxon,C., Pagels,J., Gudmundsson,A., Asbach,C., John,A.C., Kuhlbusch,T.A.J., Karlsson,J.E., Kammer,R., Tinnerberg,H., Nielsen,J., Bohgard,M. Characteristics of welding fume aerosol investigated in three Swedish workshops, Journal of Physics 2009: Conference Series 151, p Jönsson LS, Nielsen J, Broberg K. Gene expression analysis in induced sputum from welders with and without airway-related symptoms. Int Arch Occup Environ Health 2010 Sep 23. [Epub ahead of print). Frisörkemikalier/Hairdressing Eriksson A, Rylander L, Nielsen J, Hagmar L, Brisman J, Lillienberg L, Torén K, Albin M. Reproductive outcome among female hairdressers. International Conference on Womens Health Reykjavik Iceland, maj Albin M, Brisman J, Kronholm Diab K, Meding B, Mikoczy Z, Nielsen J, Torén K. Astma och eksem hos frisörer. Hygiea, band 107, häfte 1, 1998, s137. Nielsen J, Albin M, Brisman J Mikoczy Z, Rylander L, Brisman J, Kronholm Diab K, Lillienberg L, Meding B, Torén K. Asthma in hairdressers. 26 th International Congress on Occupational Health 27August 1 September 2000, Singapore.

6 Nielsen J, Albin M, Brisman J, Kronholm Diab K, Lillienberg L, Meding B, Mikoczy Z, Rylander L, Torén K. Incidens av luftvägsbesvär hos frisörer. Svenska Läkaresälskapets Riksstämma 29 november till 1 december Hygiea 2000; 109:144. Meding B, Albin M, Brisman J, Kronholm Diab K, Lillienberg L, Mikoczy Z, Nielsen J, Rylander L, Torén K. Handeksem hos frisörer - En retrospektiv kohortstudie. Svenska Läkaresälskapets Riksstämma 29 november till 1 december Hygiea 2000; 109:167. Albin M, Rylander R, Mikozcy Z, Lillienberg L, Dahlman Höglund A, Brisman J, Thore n K, Meding B, Kronholm K, Nielsen J. Asthma in hairdressers. Occup Environ Med 2002;59: Lillienberg L, Dahlman Höglund A, Mikoczy Z, Nielsen J. Ventilation i frisörsalonger och exponering för persulfater vid blondering. Svenska Läkaresälskapets Riksstämma 27 november till 29 november Hygiea 111:125. Meding B, Lind M-L, Albin M, Kronholm Diab K, Mikoczy Z, Nielsen J, Rylander L, Brisman J, Lilienberg, Torén K. Hand eczema in female hairdressers. Women Work & Health in Stockholm 2002, 2-5 June. C Bildt, L Gonäs, L Karlqvist, H Westberg (eds), Arbetslivsinstitutet pp Brisman J, Albin M, Rylander L, Mikoczy Z, Lillienberg L, Dahlman Höglund A, Torén K, Meding B, Kronholm Diab K, Nielsen J. The incidence of respiratory symptoms in female Swedish hairdressers. Am J Ind Med 2003; 44: M-L Lind, M Albin, J Brisman, K Kronholm Diab, L Lilienberg, Z Mikoczy, J Nielsen, L Rylander, K Torén, B Meding. Incidence of hand eczema in female Swedish hairdressers. Occup. Environ. Med. 2007; 64: Kronholm Diab K, Truedsson L, Albin M, Nielsen J. Persulphate challenge in female hairdressers with nasal hyperreactivity suggests immune cell - but no IgE reaction". Int Arch Occup Environ Health (Epub2008) 2009; 82: Jönsson L S, Broberg K, Paulsson K, Kronholm Diab K, Nielsen J. Gene expression in nasal lavage from hairdressers exposed to persulfate. Int Arch Occup Environ Health 2009 Epub, ahead of print. Kåredal MH, Mörtstedt H, Jeppsson MC, Kronholm Diab K, Nielsen J, Jönsson BA, Lindh CH. Time- Dependent Proteomic itraq Analysis of Nasal Lavage of Hairdressers Challenged by Persulfate. J Proteome Res Sep 22. [Epub ahead of print] Nanopartiklar/Nanoparticles Bohgard M, Nielsen J, Andersson UBK, Assarsson E, Berglund M, Broberg K, Dahl A, Dierschke K, Gudmundsson A, Hagerman I, Isaxon C, Karlsson JE, Kristiansson MH, Jönsson BAG, Jönsson LS, Löndahl J, Pagels J, Swietlicki E, Tinnerberg H, Wierzbicka A. Method for exposure chamber studies to examine effects on humans of airborne nanoparticles from welding and burning candles. The 11th International Conference on Indoor Air Quality and Climate Abstract. Bohgard M, Nielsen J, Andersson UBK, Assarsson E, Berglund M, Dahl A, Dierschke K, Gudmundsson A, Hagerman I, Isaxon C, Jönsson BAG, Löndahl J, Pagels J, Swietlicki E, Tinnerberg H, Wierzbicka A. Methodology for examination of respiratory and cardiovascular effects of airborne nanoparticles abundant in indoor environments. European Aerosol Conference, Thessaloniki, Greece Abstract Asbach C, John AC, Pagels J, Isaxon C, Gudmundsson A, Karlsson JE, Tinnerberg H, Nielsen J, Kuhlbusch TAJ, Bohgard M. Particle size distribution and surface area concentration in welding fumes measured in real workplaces with high time resolution. European Aerosol Conference, Thessaloniki, Greece Abstract

7 Trädamm Andersson U, Åkerberg E-M, Bergendorf U, Nielsen J. Ögon och luftvägsbesvär vid arbete med mjuka träslag inom träindustrin. Rapport från AMM, Labmedicin Lund; 2010 Övriga vetenskabliga arbeten/other studies Dahlqvist M, Alexandersson R, Nielsen J, Hedenstierna G. Single and multiple breath nitrogen washout - closing volume and volume of trapped gas for detection of early airway obstruction. Clinical Physiology 1989; 9: Horstman V, Nielsen J, Skerfving S. Analysis of bronchial response to metacholine challenges in an epidemiological study. Report from Department of Occupational and Environmental Medicine, University Hospital Lund 1997; 70. Olin A-C, Torén K, Ljungkvist G, Nielsen J. Measuresment of nasal nitric oxide. ERS Annual congress, Geneva, Schwitzerland, September Eur respir J 1998; 12 Suppl 28:249. Malmberg B, Nielsen J. Hud och luftvägssymptom hos tandvårdspersonal vid övergång från amalgam till akrylat. Svenska Läkaresälskapets Riksstämma 30 november till 2 december 1999.Hygiea 1999; 108:139. ANDRA PUBLIKATIONER/Other publications Hagmar L, Nielsen J, Skerfving S. Clinical features and epidemiology of occupational obstuctive respiratory disease caused by small molecular weight organic chemicals. Epidemiology of allergic diseases. Momogr Allergy 1987;21: Nielsen J. Respiratory effects in workers exposed to organic acid anhydrides. Doktors avhandling, försvarad vid Lunds universitet ISBN Nielsen J, Wass U, Belin L. Yrkesastma: I Astma - Klinik behandling; Kjell Larsson; Draco Läkemedel AB Hjärt lungfonden ISBN Skerfving S, Welinder H, Jönsson G, Nielsen J, Littorin M. De vanligsta lågmolekyläre luftvägsallergen. Toxikologisk bedömning av allergen. Rapport från kemikalieinspektionen 4/98, kap 1.3,s