Innovationer i akademisk miljö och Science for Life Lab Prof Mathias Uhlen Science for Life Lab and AlbaNova University Center Royal Institute of Technology (KTH) Stockholm, Sweden
Swedish economy is based on innovation > 50% of Gross National Product (GDP) comes from export Forestry/Paper Mining/Metal/Machinery Trade Transport/Vehicles Aeoroplanes/Weapons Pharma/Biotech ICT Environment/CleanTech
Swedish net export of pharmaceuticals
Statlig FoU-finansiering (civil)
Andel medicinska artiklar (impakt>6)
Andel (%) US-patent inom området läkemedel
Det vetenskapliga landskapet förändras 1998 2008 Source: OECD (2010), Measuring Innovation: A New Perspective, Paris. SIZE OF BUBBLE = Number of scientific publications THICKNESS OF LINK = Number of co-authorship
Antal medicinska artiklar (impakt >6)
EU-finansiering Stockholm-Uppsala till livsvetenskaper participates in (2008) 28% of the 680 projects in EU s framework 6 program Life Science & Health Region Projects Proportion 1.Paris 337 50% 2.London 254 37% 3.Stockholm-Uppsala 189 28% 4.Medicon Valley 162 24% 5.Milano / Turino 159 23% 6.München 156 23% 7.Heidelberg 135 20% 8.Madrid 117 17% 9.Rom 111 16% 10.Barcelona 104 15% Source: EuroBiotechNews (2009) 8 (3-4) 10
Uppsala Stockholm region Stockholm- Uppsalaregionen 60% av life scienceindustrin finns i Stockholm-Uppsalaregionen. 50% av alla forskningsanslag går hit och 50% av Sveriges disputerade bor här.
Den svenska paradoxen och några trender En dokumenterat hög innovationsnivå Många större bolag med betydande teknikinnehåll Många avknoppningar från universitet men få som växer Det svenska timglaset (avsaknad av mellanstora bolag) Kraftig tendens från väst till öst
Egna erfarenheter från innovationer Professor, KTH Leder fyra akademiska center Science for Life Laboratory (strategisk satsning) Human Protein Atlas projekt (Wallenberg stiftelsen) ProNova (Vinnova excellens-center) KTH Center for Biosustainability (Novo Nordisk stiftelsen) Internationell finasiering National Cancer Institute (US) National Institute of Health (US) Sjunde ram-programmet (åtta projekt) (EU) IMI Innovative Medicine Initiative (EU) Novo Nordisk Foundation (Denmark) Styrelsen publika börsbolag Novozymes (Danmark) Nordiag (Norge) Bure Equity (Sverige) Amersham (England) 10 avknoppningsbolag 80 patent
Erfarenheter från licensiering av innovationer 43 patent har licensierats till företag (de flesta utlandsägda) Tre större kommersiella framgångar Totalt ca 5 miljarder i exportinkomster 40 av 43 patent har inte kommersialiserats
Erfarnheter från akademiska avknoppningar Biotage (Stockholm O-list) - drug discovery and DNA-analysis Nordiag AS (Oslo-list) - robotics and automation Affibody - cancer imaging and therapy Creative Peptides (now US-based) - diabetes (phase 2 clinical trials) Visual Bioinformatics - software for functional genomics SweTree Technologies - forestry and agriculture Atlas Antibodies research reagents and diagnostics Atlas Therapeutics biotherapeutics Abclone (South Korea) antibody biosimilars Antibodypedia database portal for commercial antibodies
Erfarnhet från akademiska innovationer Lärarundantaget en svensk tillgång Relativt skonsam byråkrati Avsaknad av mjuk finansiering av tidig R&D Licensiering av patent svårt Entrepenörskap (avknoppningar) en berg-och-dal-bana Ingen magisk formel varje resa unik
Vetenskapen har alltid försökt att systematisera naturen 1700-talet biologi (Linné) 1800-talet kemi (Berzelius) 1900-talet - fysik 2000-talet - medicin
The building blocks of life DNA/RNA Proteins Cells Organism Molecule Information Function Building-block DNA Digital Memory 4 bases Protein Analogue Chemistry 20 amino acids
Kartläggning av DNA har exploderat Pyrosequencing: Ronaghi, Uhlen & Nyren (1998) Science 281, 363-365.
Generated with 454 (pyrosequencing) Personalized genomics
26 SEPTEMBER 2008 VOL 321 PAGES 1758-1761 Stort behov av att kartlägga människans proteiner
More than 98% of drugs directed towards proteins Leucine zipper Insulin HIV Reverse Transcriptase 20,300 genes coding for human proteins Summary of all pharma protein targets: <5% Proteins not yet studied (no literature): 40% A need for global analysis of human proteins
Science for Life Laboratory Nytt resurscenter för storskalig molekylär biovetenskap Finansierat av strategiska medel från regering (2010-2014) Fyra universitet i samarbete (Karolinska, KTH, SU och UU) Science 328,805 (14 May 2010)
SciLifeLab 2013 Science 336, 136 (13 April, 2012) New funding from 2013 Approximately 700 researchers (end of 2013) Infrastructure for genomics, proteomics, metabolomics Nature 484, 171 (12 April, 2012)
Hagastaden ett nav för life science Tillsammans skapar det av Europas största campus med 70 000 studenter och 7 000 forskare
Science for Life Lab translational medicine Board SAB NRK Managing Directors Translational Medicine Biological processes Genomics and genetics Infrastructure programs (platforms) Proteomics and bioimaging Drug development and functional biology Bioinformatics
Population-based biobanks (> 10 000 participants) Many biobank repositories in Scandinavia (with high quality clinical records) Only 2-4% of Swedish population decline biobanking! Source: P 3 G Observatory
Diagnosis Treatment Phenotyping of patients Follow up Patient data Studies on complex diseases, Development of novel drugs Clinics/Universities Bioinformatics Results Implementation Experimental data The Clinics/ Universities Patients Science for Life Laboratory Genes, proteins, sequences Imaging, Models Biobanking and biomolecular resources research infrastructure BBMRI.SE Samples incl. tissue
Expected outcome/benefits for society An individual treatment to an individual patients Stratify patients into responders and non-responders Develop diagnostic test for choice of treatment (or dose) Avoid treatment of patients which will have serious side-effects An estimated 90% of drugs currently on the market work in only ~40% of individuals translating annually into $350 billion worth of ineffective prescriptions. Nature Biotechnology 30:1 (2012)
The Human Protein Atlas project Finansiering från Knut och Alice Wallenbergs Stiftelse med start 2003 Sju enheter: KTH, Uppsala, KI, Lund, Seoul, Shanghai och Mumbai Även finansiering från fakultet, EU (7 program), VR, NCI och NIH Ca 100 personer I Stockholm och Uppsala Det enda projektet i världen i sitt slag
The Protein Atlas team ett nätverk av forskare Sweden (four sites) Seoul site 10 research groups in US Hangzhou site 20 research groups in Europe Mumbai site
Mumbai Dr. Sanjay Navani Certified pathologists Web-based annotation Analyze 10,000 images per day
The subcellular distribution of proteins Emma Lundberg Knowledge about the subcellular localization of a protein is important for: functional understanding of proteins interaction maps understanding cellular processes and pathways characterizing the organelles and subcompartments
Nuclear
Actin filaments
Profiling using tissue micro arrays (IHC) Caroline Kampf
Human CD47
En milstolpe uppnåddes i september 70 % av alla människans gener 14,047 gener
The progress of the Protein Atlas First draft of the human proteome by 2015 (20,000 genes)
SciLifeLab - four infrastructure Programs Board SAB NRK Managing Directors Translational Medicine Environmental research Genomics and genetics Infrastructure programs (platforms) Proteomics and bioimaging Drug development and functional biology Bioinformatics
A three-dimensional map of the Baltic Sea bacteriome 16S rdna 454 sequencing 3-4 depths at 60 stations in July Surface water communities cluster according to salinity Strong community shifts along the oxygen gradient Closely related populations occupy different salinity ranges (Here two members of the cosmopolitan SAR11 clade) [O 2 ]
Butanol från solljus OH hv CO2 Josefine Anfelt O O OH n
Metabolic Engineering Modeling & Design Genome-scale metabolic models Kinetic models Thermodynamics Flux balancing Strain Construction Chromosome integrated modification Tv = b dc prod dt = k f C react - k r C prod Plasmid Reference Omics Analysis Genome sequencing RNA sequencing DNA arrays Proteomics Metabolomics Fluxomics Fermentation Time
Summering Nytt center med nationellt ansvar med start 2013 Nya strategier för translationell forskning Stratifiering av patienter för mer effektiv behandling Kartläggning av människans alla byggstenar Behov av multi-disciplinära samarbeten
King Carl XVI Gustav identifies the curly form of the b-amylod protein at 20 000 times magnification
Thanks for your attention!